The library was prepared on the base of Otava and Life Chemicals Stock Collections (about 500,000 compounds total) using receptor-based virtual screening.
Design of the focused libraries consists in Lipinsky/Veber rules filtering and flexible docking in a protein target of certain enzyme family. Further computational analysis for the presence of critical receptor-ligand hydrogen bond(s) and docking score refinement makes our focused libraries good starting point for drug discovery purposes
Continue Reading November 20th, 2007
Food and Drug administration announced the approval of erectile dysfunction drug Viagra (sildenafil citrate), the first oral drug for erectile dysfunction, a dysfunction that millions of peoples affect in United States.
Viagra was evaluated in group of randomly taken person, placebo controlled trials involving more than 3000 men with varying degrees of erectile dysfunction associated with spinal cord injury, diabetes, history of prostate surgery, and no identifiable organic cause of impotence. Patients also had other related disease including hypertension and coronary artery disease. . The findings were consistent in men representing a wide range of severity and etiology of their impotence (erectile dysfunction).
Some patients from randomly taken group on Viagra (about 3 percent) also reported changes in vision, principally altered color perception.
Continue Reading October 29th, 2007
It has been estimated that more than 57% of diabetic men suffer from erectile dysfunction-also called impotence and almost all complain bitterly that it has destroyed something that is very important to them. Erectile dysfunction caused by diabetes can be prevented in almost all men whose bodies can still make insulin.
Diabetes occurs when you body is not capable to produce insulin. Insulin is basically a hormone necessary to convert sugar and starches into energy, which is required to make yours body work efficiently.
The main risk factors for developing erectile dysfunction in men with diabetes are:
Nerve damage: Long-term diabetes also causes nerve damage, which may be a contributing factor.
Blood vessel damage.
Reduced blood sugar control.
But there are some treatments available for men with diabetes and erectile dysfunction. Men with diabetes having problem develop or maintain an erection can take oral ED drug such as Viagra, Cialis and Levitra. Additional treatment in men with diabetes might want to consider include intracavernous injection therapy, vacuum constriction devices, intraurethral therapy, and sex therapy.
Continue Reading October 29th, 2007
In present, Impotence is getting to be a more and more common dysfunction. Over long period impotence known under many nick names and feared by man who seeks to pleasure sex.
Impotence problem can occur for many reasons. Often impotence problem will have more than one cause. Basically causes may be psychological, physical or a combination of both. For successful treatments there is need of Distinguishing between causes.
Psychogenic Impotence
The best known psychological factors that cause impotence are stress and lack of confidence. For example, a sexually active man gradually find himself unable to achieve erection or maintain erection due to losing his job .It is possible to for the mans stress and worry when he attempt intercourse. So stress and lack of confidence breaks the focus needed for sex and puts all efforts in doubt.
Physical or Organic Impotence
The most common cause of this inability is poor circulation and flow of blood inability to develop or maintain erection in men. Anything that slows or to make less blood flow can bring about impotence or erectile dysfunction. Common causes this include diabetes, vascular problem, high blood pressure, lipid problems and smoking. So if your blood pressure high, please maintain it in specified range. Diabetes causes ED by affecting both the nerves and blood vessels. Diabetes damage small nerves and blocked small vessels through it normally have less blood flow to the penis and by damage small nerves have less ability to dilate those vessels on demand. Smoking is also another major factor to lead ED, many studies shown.
Medications can also cause ED. (blood pressure pills, cold medications, hormones, antidepressants, tranquilizers, alcohol, heroin and cocaine).
Continue Reading October 29th, 2007
Scientists say initial report of death related with Viagra use soon after the Viagra was released caused physicians to hesitate before prescribing it to patients with heart disease.
Though it is clear that drug does not increase heart related deaths, say researcher Linda J. Webster, and cMscN, of the University of Alberta.
In this recent study, Scientists looked at the effect treating ED with in a group of 35 men with mild to judicious heart failure who didnt use nitrates .This group randomly divided into two groups:
One group took Viagra for six weeks and then switched to a placebo for six weeks, and second group took a placebo for six weeks and took Viagra for another six week.
The results appeared in the March issue of the Archives of Internal Medicine.
The study revealed Viagra (Sildenafil) caused an average drop in pressure of about 6.5-9 mm Hg for the systolic blood pressure and 2.5-4 mmHg for the diastolic pressure.
Now researchers found Viagra improved ED and quality of life among this group and also decreased symptoms of depression.
This study provides new evidence that Viagra is safe and effective to treat men with ED.
Continue Reading October 29th, 2007
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